1) Final Fantasy XII - Featuring a 2 hour long demo and an amazing new trailer, FFXII had one of the best presentations of any game at E3, and has already won Best of Show from a number of different websites. I'm really excited to see the FF series go in a new direction. Famous producer of Vagrant Story, Final Fantasy Tactics, and the Ogre Battle series will be leading this game's development, looks to be shaping up very nicely.
2) Zelda - Don't think I need to explain anything.
3) Fable - Where to begin? Well this is the massive RPG project being worked on by the development company Big Blue Box for a large number of years now. Acclaimed to be "the best RPG ever made". Complete and ultimate freedom to do whatever you want and be whoever you want.
4) Metal Gear Solid 3 - Looks awesome. Prequel to MGS1 for PSone, story of Big Boss during the Cold War. Takes place in the jungle with extremely creative tactical stealth techniques. Can't wait.
5) Halo 2 - This needs no explanation.
6) Silent Hill 4 - Absolutely horrorfying. Unbelievable style. Can't wait to be scared sh*tless.
7) Star Ocean 3 - Whee.
8) Suikoden IV - Suhweet.
9) Metroid Prime 2 - Yep.
10) Resident Evil 4 - Can you tell I'm getting lazy?