[Professor S]

Going a little more in detail:

Weapons

Guns
30/6 Hunting rifle for long range with makeshift silencer
.357 Magnum (silenced) for medium range and concvenience
Sawed off 10 guage shotgun for stopping power and path clearing if cornered

Melee
Machete - Heavy blade for chopping, and a wide cutting area reducing the need for accuracy in a close fight.
Polearm (long stick with a sword or large cutting blade attached) - Good for keep nasties away from boats, cars and second floors
Brick hammer - The finishing blow once they're inapacitated