Well I've been playing Super Mario Galaxy this morning, in 1080p.

I'm also using a real controller, and I've mapped the shake to a button.
I have news for you folks - doing a spin attack by pressing a button is actually easier, more fun, and more accurate than doing it by shaking the wii mote. Glad we settled that.
I actually can't run the game in x3 the internal resolution, even though my machine is kind of beastly. I have a core i7 processor. Graphics card isn't amazing, but isn't terrible either.
Right now I'm sticking with x2 internal res and no anti-aliasing. My game stays in the 45 - 50 fps range, although it gets super laggy curing cut scenes. Luckily there aren't many of those.
Also, I mapped the pointing of the wii mote to an analog stick, but that isn't working so great yet. I feel like I need to turn down the sensitivity of the analog stick, but I'm not sure if I can do that with this gamepad.
Anyone have any recommendations for settings SMG? I'm pretty pleased with it as is, but I'd be up for making it even better.