Movies/Shows That Take Place in Your City

[The Germanator]

Hmm...

Philadelphia:
Rocky + sequels (obvious)
Philadelphia (more obvious??)
12 Monkeys
All M. Night Shyamalan films (He grew up in the area. I got to drink to the new year on a bar on the set of The Village, it was awesome)
National Treasure

TV Shows in Philly:

Cold Case (not anymore I think, but was filmed in Philly for the majority)
It's Always Sunny in Philadelphia (obvious, but awesome)

Stuff in Wilmington, DE:

Not really sure, but I know one X-files episode was based in Wilmington.